Ontology highlight
ABSTRACT:
SUBMITTER: Armstrong RJ
PROVIDER: S-EPMC6771629 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20190807 36
Hydrogen borrowing catalysis serves as a powerful alternative to enolate alkylation, enabling the direct coupling of ketones with unactivated alcohols. However, to date, methods that enable control over the absolute stereochemical outcome of such a process have remained elusive. Here we report a catalytic asymmetric method for the synthesis of enantioenriched cyclohexanes from 1,5-diols via hydrogen borrowing catalysis. This reaction is mediated by the addition of a chiral iridium(I) complex, wh ...[more]