Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC6771933 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Wang Huiyun H Zhang Xuexin X Xue Li L Xing Juan J Jouvin Marie-Hélène MH Putney James W JW Anderson Matthew P MP Trebak Mohamed M Kinet Jean-Pierre JP
Immunity 20160329 4
Activation of T cells is mediated by the engagement of T cell receptors (TCRs) followed by calcium entry via store-operated calcium channels. Here we have shown an additional route for calcium entry into T cells-through the low-voltage-activated T-type CaV3.1 calcium channel. CaV3.1 mediated a substantial current at resting membrane potentials, and its deficiency had no effect on TCR-initiated calcium entry. Mice deficient for CaV3.1 were resistant to the induction of experimental autoimmune enc ...[more]