Ontology highlight
ABSTRACT:
SUBMITTER: Jakubowiak AJ
PROVIDER: S-EPMC6772147 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Jakubowiak Andrzej J AJ Jasielec Jagoda K JK Rosenbaum Cara A CA Cole Craig E CE Chari Ajai A Mikhael Joseph J Nam Jennifer J McIver Amanda A Severson Erica E Stephens Leonor A LA Tinari Kathryn K Rosebeck Shaun S Zimmerman Todd M TM Hycner Tyler T Turowski Agata A Karrison Theodore T Zonder Jeffrey A JA
British journal of haematology 20190524 4
Selinexor, an oral Selective Inhibitor of Nuclear Export, targets Exportin 1 (XPO1, also termed CRM1). Non-clinical studies support combining selinexor with proteasome inhibitors (PIs) and corticosteroids to overcome resistance in relapsed/refractory multiple myeloma (RRMM). We conducted a phase I dose-escalation trial of twice-weekly selinexor in combination with carfilzomib and dexamethasone (SKd) to determine maximum tolerated dose in patients with RRMM (N = 21), with an expansion cohort to a ...[more]