Ontology highlight
ABSTRACT:
SUBMITTER: Richter J
PROVIDER: S-EPMC7285937 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Richter Joshua J Madduri Deepu D Richard Shambavi S Chari Ajai A
Therapeutic advances in hematology 20200609
Multiple myeloma (MM) represents an incurable hematologic malignancy. Despite significant advances over the past decade, with the advent of multiple new classes of anti-myeloma agents, including immunomodulatory drugs, proteasome inhibitors and monoclonal antibodies, patients ultimately relapse. Selinexor is a first-in-class exportin-1 inhibitor with activity in these multiply relapsed and refractory patients. Although the current Food and Drug Administration (FDA) approval is for the doublet of ...[more]