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Highly Enantioselective Catalytic Addition of Grignard Reagents to N-Heterocyclic Acceptors.

ABSTRACT: General methods to prepare chiral N-heterocyclic molecular scaffolds are greatly sought after because of their significance in medicinal chemistry. Described here is the first general catalytic methodology to access a wide variety of chiral 2- and 4-substituted tetrahydro-quinolones, dihydro-4-pyridones, and piperidones with excellent yields and enantioselectivities, utilizing a single catalyst system.

SUBMITTER: Guo Y

PROVIDER: S-EPMC6772156 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Highly Enantioselective Catalytic Addition of Grignard Reagents to N-Heterocyclic Acceptors.

Guo Yafei Y Harutyunyan Syuzanna R SR

Angewandte Chemie (International ed. in English) 20190730 37

General methods to prepare chiral N-heterocyclic molecular scaffolds are greatly sought after because of their significance in medicinal chemistry. Described here is the first general catalytic methodology to access a wide variety of chiral 2- and 4-substituted tetrahydro-quinolones, dihydro-4-pyridones, and piperidones with excellent yields and enantioselectivities, utilizing a single catalyst system. ...[more]

PMID: 31257687

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