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Palladium-catalyzed asymmetric conjugate addition of arylboronic acids to heterocyclic acceptors.

ABSTRACT: Flava Flavanone: Asymmetric conjugate additions to chromones and 4-quinolones are reported utilizing a single catalyst system formed in situ from Pd(OCOCF(3))(2) and (S)-tBuPyOX. Notably, these reactions are performed in wet solvent under ambient atmosphere, and employ readily available arylboronic acids as the nucleophile, thus providing ready access to these asymmetric heterocycles (see scheme).

SUBMITTER: Holder JC

PROVIDER: S-EPMC3753812 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Palladium-catalyzed asymmetric conjugate addition of arylboronic acids to heterocyclic acceptors.

Holder Jeffrey C JC Marziale Alexander N AN Gatti Michele M Mao Bin B Stoltz Brian M BM

Chemistry (Weinheim an der Bergstrasse, Germany) 20121203 1

Flava Flavanone: Asymmetric conjugate additions to chromones and 4-quinolones are reported utilizing a single catalyst system formed in situ from Pd(OCOCF(3))(2) and (S)-tBuPyOX. Notably, these reactions are performed in wet solvent under ambient atmosphere, and employ readily available arylboronic acids as the nucleophile, thus providing ready access to these asymmetric heterocycles (see scheme). ...[more]

PMID: 23208950

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