The functional ClpXP protease of Chlamydia trachomatis requires distinct clpP genes from separate genetic loci.
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ABSTRACT:
SUBMITTER: Pan S
PROVIDER: S-EPMC6773864 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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The functional ClpXP protease of Chlamydia trachomatis requires distinct clpP genes from separate genetic loci.
Pan Stefan S Malik Imran T IT Thomy Dhana D Henrichfreise Beate B Sass Peter P
Scientific reports 20191001 1
Clp proteases play a central role in bacterial physiology and, for some bacterial species, are even essential for survival. Also due to their conservation among bacteria including important human pathogens, Clp proteases have recently attracted considerable attention as antibiotic targets. Here, we functionally reconstituted and characterized the ClpXP protease of Chlamydia trachomatis (ctClpXP), an obligate intracellular pathogen and the causative agent of widespread sexually transmitted diseas ...[more]
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