Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids.
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ABSTRACT:
SUBMITTER: Demiray M
PROVIDER: S-EPMC6774066 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids.
Demiray Melodi M Miller David J DJ Allemann Rudolf K RK
Beilstein journal of organic chemistry 20190917
8-Methoxy-γ-humulene, (<i>E</i>)-8-methoxy-β-farnesene, 12-methoxy-β-sesquiphellandrene and 12-methoxyzingiberene can be synthesised in amorphadiene synthase-catalysed reactions from 8- and 12-methoxyfarnesyl diphosphates due to the highly plastic yet tightly controlled carbocationic chemistry of this sesquiterpene cyclase. ...[more]
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