Ontology highlight
ABSTRACT:
SUBMITTER: Grathwol CW
PROVIDER: S-EPMC6774072 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20190916
The use of light as an external trigger to change ligand shape and as a result its bioactivity, allows the probing of pharmacologically relevant systems with spatiotemporal resolution. A hetero-stilbene lead resulting from the screening of a compound that was originally designed as kinase inhibitor served as a starting point for the design of photoswitchable sirtuin inhibitors. Because the original stilbenoid structure exerted unfavourable photochemical characteristics it was remodelled to its h ...[more]