Ontology highlight
ABSTRACT: Purpose
Among a cohort of postmenopausal breast cancer survivors, we aimed to compare the risk of dementia associated with aromatase inhibitor (AI) therapy versus tamoxifen.Methods
Using UK primary care electronic health records, we identified 14,214 postmenopausal breast cancer survivors (aged ??54 years) with a first AI or tamoxifen prescription between January 2002 and December 2015 and no previous dementia diagnosis. Women were followed-up to identify incident cases of dementia. Cox regression was used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs) to quantify the association between AI exposure (vs. tamoxifen) and dementia, adjusted for confounders.Results
A total of 368 incident dementia cases was identified over 57,102 person-years of follow-up. The crude incidence rate of dementia was 7.46 per 1000 person-years (95% CI 6.43-8.65) among women starting endocrine treatment on an AI, and 6.32 per 1000 person-years (95% CI 5.34-7.47) among women starting on tamoxifen. After accounting for age differences and assessing other potential confounders, there was no evidence of a difference in dementia risk between exposure groups (HR for AI vs tamoxifen 1.04, 95% CI 0.83-1.03). There was no evidence of effect modification by age.Conclusion
There was no evidence for a difference in dementia risk between AI and tamoxifen users among postmenopausal breast cancer survivors.Implications for cancer survivors
Our findings suggest that there is no reason for concern about a difference in dementia risk with AI vs. tamoxifen, which is relevant to postmenopausal breast cancer patients recommended these treatments.
SUBMITTER: Bromley SE
PROVIDER: S-EPMC6776493 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Bromley Susan E SE Matthews Anthony A Smeeth Liam L Stanway Susannah S Bhaskaran Krishnan K
Journal of cancer survivorship : research and practice 20190718 4
<h4>Purpose</h4>Among a cohort of postmenopausal breast cancer survivors, we aimed to compare the risk of dementia associated with aromatase inhibitor (AI) therapy versus tamoxifen.<h4>Methods</h4>Using UK primary care electronic health records, we identified 14,214 postmenopausal breast cancer survivors (aged ≥ 54 years) with a first AI or tamoxifen prescription between January 2002 and December 2015 and no previous dementia diagnosis. Women were followed-up to identify incident cases of dement ...[more]