Ontology highlight
ABSTRACT:
SUBMITTER: Li B
PROVIDER: S-EPMC6776513 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Li Bo B Lee Carol C Cadete Marissa M Zhu Haitao H Koike Yuhki Y Hock Alison A Wu Richard Y RY Botts Steven R SR Minich Adam A Alganabi Mashriq M Chi Lijun L Zani-Ruttenstock Elke E Miyake Hiromu H Chen Yong Y Mutanen Annika A Ngan Bo B Johnson-Henry Kathene C KC De Coppi Paolo P Eaton Simon S Määttänen Pekka P Delgado-Olguin Paul P Sherman Philip M PM Zani Augusto A Pierro Agostino A
Cell death & disease 20191003 10
Necrotizing enterocolitis (NEC) is a devastating neonatal disease characterized by acute intestinal injury. Intestinal stem cell (ISC) renewal is required for gut regeneration in response to acute injury. The Wnt/β-catenin pathway is essential for intestinal renewal and ISC maintenance. We found that ISC expression, Wnt activity and intestinal regeneration were all decreased in both mice with experimental NEC and in infants with acute active NEC. Moreover, intestinal organoids derived from NEC-i ...[more]