Ontology highlight
ABSTRACT:
SUBMITTER: Proto WR
PROVIDER: S-EPMC6778099 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Nature communications 20191004 1
Plasmodium species are frequently host-specific, but little is currently known about the molecular factors restricting host switching. This is particularly relevant for P. falciparum, the only known human-infective species of the Laverania sub-genus, all other members of which infect African apes. Here we show that all tested P. falciparum isolates contain an inactivating mutation in an erythrocyte invasion associated gene, PfEBA165, the homologues of which are intact in all ape-infective Lavera ...[more]