Dataset Information

Expression Of Intracellular Components of the NF-?B Alternative Pathway (NF-?B2, RelB, NIK and Bcl3) is Associated With Clinical Outcome of NSCLC Patients.

ABSTRACT: A growing number of studies has shed light on the role of the NF-?? in non-small-cell lung cancer (NSCLC). To address the significance of major effectors of the NF-?? alternative pathway, we investigated the relationship between NF-??2, RelB, NIK and Bcl3 expression (mRNA and protein) and the clinical outcome of NSCLC patients. NF-??2, RelB, NIK and Bcl3 protein expression levels were assessed by immunohistochemistry in tissue samples from 151 NSCLC patients who had curative resection. mRNA levels were also evaluated in 69 patients using quantitative real-time PCR. Although all studied proteins were overexpressed in NSCLC (P?

SUBMITTER: Dimitrakopoulos FD

PROVIDER: S-EPMC6778110 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Expression Of Intracellular Components of the NF-κB Alternative Pathway (NF-κB2, RelB, NIK and Bcl3) is Associated With Clinical Outcome of NSCLC Patients.

Dimitrakopoulos Foteinos-Ioannis D FD Antonacopoulou Anna G AG Kottorou Anastasia E AE Panagopoulos Nikolaos N Kalofonou Fotini F Sampsonas Fotios F Scopa Chrisoula C Kalofonou Melpomeni M Koutras Angelos A Makatsoris Thomas T Dougenis Dimitrios D Papadaki Helen H Brock Malcolm M Kalofonos Haralabos P HP

Scientific reports 20191004 1

A growing number of studies has shed light on the role of the NF-κΒ in non-small-cell lung cancer (NSCLC). To address the significance of major effectors of the NF-κΒ alternative pathway, we investigated the relationship between NF-κΒ2, RelB, NIK and Bcl3 expression (mRNA and protein) and the clinical outcome of NSCLC patients. NF-κΒ2, RelB, NIK and Bcl3 protein expression levels were assessed by immunohistochemistry in tissue samples from 151 NSCLC patients who had curative resection. mRNA leve ...[more]

PMID: 31586084

Dataset Information

Expression Of Intracellular Components of the NF-?B Alternative Pathway (NF-?B2, RelB, NIK and Bcl3) is Associated With Clinical Outcome of NSCLC Patients.

Publications

Expression Of Intracellular Components of the NF-κB Alternative Pathway (NF-κB2, RelB, NIK and Bcl3) is Associated With Clinical Outcome of NSCLC Patients.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Similar Datasets

RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation.
| S-EPMC2268780 | biostudies-literature

Impairment of Mature B Cell Maintenance upon Combined Deletion of the Alternative NF-?B Transcription Factors RELB and NF-?B2 in B Cells.
| S-EPMC4779691 | biostudies-literature

Lymphotoxin-β receptor-NIK signaling induces alternative RELB/NF-κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer.
| S-EPMC7066987 | biostudies-literature

Lymphotoxin-? receptor signaling through NF-?B2-RelB pathway reprograms adipocyte precursors as lymph node stromal cells.
| S-EPMC3809035 | biostudies-literature

Hodgkin lymphoma requires stabilized NIK and constitutive RelB expression for survival.
| S-EPMC3488888 | biostudies-other

NIK promotes tissue destruction independently of the alternative NF-?B pathway through TNFR1/RIP1-induced apoptosis.
| S-EPMC4816116 | biostudies-literature

Differential utilization of NF-kappaB RELA and RELB in response to extracellular versus intracellular polyIC stimulation in HT1080 cells.
| S-EPMC3048558 | biostudies-literature

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.
| S-EPMC2671996 | biostudies-literature

APPL1 regulates basal NF-?B activity by stabilizing NIK.
| S-EPMC3482318 | biostudies-literature

NIK/NF-kappaB2 regulated gene products.
2008-03-05 | GSE7219 | GEO