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The role of ?-helices in TRP channel gating.

ABSTRACT: Transient Receptor Potential (TRP) channels are a large superfamily of polymodal ion channels, which perform important roles in numerous physiological processes. The architecture of their transmembrane (TM) domains closely resembles that of voltage-gated potassium channels (KV). However, recent cryoEM and crystallographic studies of TRP channels have identified ?-helices in functionally important regions, and it is increasingly recognized that they utilize a distinct mechanism of gating that relies on ?-to-? secondary structure transitions. Here we review our current understanding of the role of ?-helices in TRP channel function and their broader impact on different classes of ion channels.

SUBMITTER: Zubcevic L

PROVIDER: S-EPMC6778516 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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The role of π-helices in TRP channel gating.

Zubcevic Lejla L Lee Seok-Yong SY

Current opinion in structural biology 20190802

Transient Receptor Potential (TRP) channels are a large superfamily of polymodal ion channels, which perform important roles in numerous physiological processes. The architecture of their transmembrane (TM) domains closely resembles that of voltage-gated potassium channels (K<sub>V</sub>). However, recent cryoEM and crystallographic studies of TRP channels have identified π-helices in functionally important regions, and it is increasingly recognized that they utilize a distinct mechanism of gati ...[more]

PMID: 31378426

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