Ontology highlight
ABSTRACT:
SUBMITTER: Magoro T
PROVIDER: S-EPMC6779448 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Magoro Tshifhiwa T Dandekar Aditya A Jennelle Lucas T LT Bajaj Rohan R Lipkowitz Gabriel G Angelucci Angelina R AR Bessong Pascal O PO Hahn Young S YS
The Journal of biological chemistry 20190802 40
Zika virus (ZIKV)<sup>3</sup> is an enveloped, single-stranded, positive-sense RNA virus of the Flaviviridae family that has emerged as a public health threat because of its global transmission and link to microcephaly. Currently there is no vaccine for this virus. Conversion of cholesterol to 25-hydroxycholesterol by cholesterol 25-hydroxylase (CH25H) has been shown to have broad antiviral properties. However, the molecular basis of induction of CH25H in humans is not known. Elucidation of sign ...[more]