Ontology highlight
ABSTRACT:
SUBMITTER: Tsarouchas TM
PROVIDER: S-EPMC6220182 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Tsarouchas Themistoklis M TM Wehner Daniel D Cavone Leonardo L Munir Tahimina T Keatinge Marcus M Lambertus Marvin M Underhill Anna A Barrett Thomas T Kassapis Elias E Ogryzko Nikolay N Ogryzko Nikolay N Feng Yi Y van Ham Tjakko J TJ Becker Thomas T Becker Catherina G CG
Nature communications 20181107 1
Spinal cord injury leads to a massive response of innate immune cells in non-regenerating mammals, but also in successfully regenerating zebrafish. However, the role of the immune response in successful regeneration is poorly defined. Here we show that inhibiting inflammation reduces and promoting it accelerates axonal regeneration in spinal-lesioned zebrafish larvae. Mutant analyses show that peripheral macrophages, but not neutrophils or microglia, are necessary for repair. Macrophage-less irf ...[more]