Ontology highlight
ABSTRACT:
SUBMITTER: Fang H
PROVIDER: S-EPMC6779695 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Fang He H Disteche Christine M CM Berletch Joel B JB
Frontiers in cell and developmental biology 20191001
X inactivation represents a complex multi-layer epigenetic mechanism that profoundly modifies chromatin composition and structure of one X chromosome in females. The heterochromatic inactive X chromosome adopts a unique 3D bipartite structure and a location close to the nuclear periphery or the nucleolus. X-linked lncRNA loci and their transcripts play important roles in the recruitment of proteins that catalyze chromatin and DNA modifications for silencing, as well as in the control of chromati ...[more]