Ontology highlight
ABSTRACT:
SUBMITTER: Wang YY
PROVIDER: S-EPMC6780492 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Wang Ya-Yun YY Lai Tsung-Hsuan TH Chen Mei-Feng MF Lee Hui-Ling HL Kuo Pao-Lin PL Lin Ying-Hung YH
Journal of clinical medicine 20190823 9
The main objective of this study was to evaluate the potential genetic effects of <i>SEPT14</i> on male infertility through sequencing the <i>SEPT14</i> coding region. To address this research gap, 254 men with sperm abnormalities and 116 normozoospermic men were recruited, and the whole-coding regions of <i>SEPT14</i> were sequenced. Two heterozygous mutations, p.Ala123Thr (3/254 vs. 0/116) and p.Ile333Thr (3/254 vs. 0/116), were identified in these cases. A high percentage of defective sperm h ...[more]