Ontology highlight
ABSTRACT:
SUBMITTER: Kana V
PROVIDER: S-EPMC6781012 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20190726 10
Microglia, the brain resident macrophages, critically shape forebrain neuronal circuits. However, their precise function in the cerebellum is unknown. Here we show that human and mouse cerebellar microglia express a unique molecular program distinct from forebrain microglia. Cerebellar microglial identity was driven by the CSF-1R ligand CSF-1, independently of the alternate CSF-1R ligand, IL-34. Accordingly, CSF-1 depletion from Nestin<sup>+</sup> cells led to severe depletion and transcriptiona ...[more]