Ontology highlight
ABSTRACT:
SUBMITTER: Yamashiro K
PROVIDER: S-EPMC7708818 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Yamashiro Kunihiko K Hori Kei K Lai Esther S K ESK Aoki Ryo R Shimaoka Kazumi K Arimura Nariko N Egusa Saki F SF Sakamoto Asami A Abe Manabu M Sakimura Kenji K Watanabe Takaki T Uesaka Naofumi N Kano Masanobu M Hoshino Mikio M
iScience 20201118 12
<i>Autism susceptibility candidate 2</i> (<i>AUTS2</i>), a risk gene for autism spectrum disorders (ASDs), is implicated in telencephalon development. Because AUTS2 is also expressed in the cerebellum where defects have been linked to ASDs, we investigated AUTS2 functions in the cerebellum. AUTS2 is specifically localized in Purkinje cells (PCs) and Golgi cells during postnatal development. <i>Auts2</i> conditional knockout (cKO) mice exhibited smaller and deformed cerebella containing immature- ...[more]