Ontology highlight
ABSTRACT:
SUBMITTER: Atkins M
PROVIDER: S-EPMC6781435 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Atkins Melody M Gasmi Laïla L Bercier Valérie V Revenu Céline C Del Bene Filippo F Hazan Jamilé J Fassier Coralie C
The Journal of cell biology 20190919 10
Neuronal connectivity relies on molecular motor-based axonal transport of diverse cargoes. Yet the precise players and regulatory mechanisms orchestrating such trafficking events remain largely unknown. We here report the ATPase Fignl1 as a novel regulator of bidirectional transport during axon navigation. Using a yeast two-hybrid screen and coimmunoprecipitation assays, we showed that Fignl1 binds the kinesin Kif1bβ and the dynein/dynactin adaptor Bicaudal D-1 (Bicd1) in a molecular complex inc ...[more]