The Kinesin KIF1Bβ links neuroblastoma and neurodegenerative disease through anterograde transport of TRKA
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ABSTRACT: We recently identified pathogenic KIF1Bb mutations in sympathetic nervous system malignancies that are defective in developmental apoptosis. Here we deleted KIF1Bb in the mouse sympathetic nervous system based on a cre recombination system driven by the dopamine beta hydroxylase (DBH) promoter. We observed impaired sympathetic nervous function and misexpression of genes required for sympathoadrenal lineage differentiation in KIF1Bb deficient sympathetic ganglia.
ORGANISM(S): Mus musculus
PROVIDER: GSE90952 | GEO | 2017/08/30
SECONDARY ACCESSION(S): PRJNA356434
REPOSITORIES: GEO
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