Ontology highlight
ABSTRACT:
SUBMITTER: Silver JT
PROVIDER: S-EPMC6781438 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Silver Jordan T JT Wirtz-Peitz Frederik F Simões Sérgio S Pellikka Milena M Yan Dong D Binari Richard R Nishimura Takashi T Li Yan Y Harris Tony J C TJC Perrimon Norbert N Tepass Ulrich U
The Journal of cell biology 20190813 10
The spatio-temporal regulation of small Rho GTPases is crucial for the dynamic stability of epithelial tissues. However, how RhoGTPase activity is controlled during development remains largely unknown. To explore the regulation of Rho GTPases in vivo, we analyzed the Rho GTPase guanine nucleotide exchange factor (RhoGEF) Cysts, the <i>Drosophila</i> orthologue of mammalian p114RhoGEF, GEF-H1, p190RhoGEF, and AKAP-13. Loss of Cysts causes a phenotype that closely resembles the mutant phenotype of ...[more]