Ontology highlight
ABSTRACT:
SUBMITTER: McCarter SD
PROVIDER: S-EPMC3392093 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Traffic (Copenhagen, Denmark) 20100227 6
The establishment of tight junctions and cell polarity is an essential process in all epithelia. Endotubin is an integral membrane protein found in apical endosomes of developing epithelia when tight junctions and epithelial polarity first arise. We found that the disruption of endotubin function in cells in culture by siRNA or overexpression of the C-terminal cytoplasmic domain of endotubin causes defects in organization and function of tight junctions. We observe defects in localization of tig ...[more]