Unknown

Dataset Information

0

The study of antimicrobial, anti-cancer, anti-inflammatory and ?-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of Nigrospora sphaerica.

ABSTRACT: A new compound, nigronapthaphenyl, was extracted from the endophytic fungus Nigrospora sphaerica isolated from a mangrove plant Bruguiera gymnorrhyza. The structure of the compound was elucidated by analysis of 1D and 2D NMR spectra and mass spectrometric data. It was tested in vitro for its antimicrobial activity, cytotoxicity, anti-inflammatory activity and for its ability to inhibit ?-glucosidase. Nigronapthaphenyl showed antibacterial activities against Bacillus subtilis TISTR 088 and Bacillus cereus TISTR 688 with MIC values of 4 and 2 ?g/mL respectively. Cytotoxicity against colon cancer cell line HCT 116 was found to be an IC50 value of 9.62 ± 0.5 ?M . This further showed potential anti-inflammatory activity amounting to an IC50 of 6.2 ± 0.5 ?M and also ?-glucosidase inhibitory activity, with an IC50 value of 6.9 ± 0.5 ?M.

SUBMITTER: Ukwatta KM 

PROVIDER: S-EPMC6781459 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The study of antimicrobial, anti-cancer, anti-inflammatory and α-glucosidase inhibitory activities of Nigronapthaphenyl, isolated from an extract of <i>Nigrospora sphaerica</i>.

Ukwatta Kushan M KM   Lawrence Jennifer L JL   Wijayarathna C D CD  

Mycology 20190524 4

A new compound, nigronapthaphenyl, was extracted from the endophytic fungus <i>Nigrospora sphaerica</i> isolated from a mangrove plant <i>Bruguiera gymnorrhyza</i>. The structure of the compound was elucidated by analysis of 1D and 2D NMR spectra and mass spectrometric data. It was tested <i>in vitro</i> for its antimicrobial activity, cytotoxicity, anti-inflammatory activity and for its ability to inhibit α-glucosidase. Nigronapthaphenyl showed antibacterial activities against <i>Bacillus subti  ...[more]

Similar Datasets

Unknown Antimicrobial metabolite profiling of Nigrospora sphaerica from Adiantum philippense L.
| S-EPMC7581665 | biostudies-literature
Genomics Nigrospora sphaerica
| PRJNA726603 | ENA
Genomics Nigrospora sphaerica
| PRJNA1091526 | ENA
Unknown Antimicrobial, Cytotoxic, and <i>α</i>-Glucosidase Inhibitory Activities of Ethanol Extract and Chemical Constituents Isolated from <i>Homotrigona apicalis</i> Propolis-In Vitro and Molecular Docking Studies.
| S-EPMC10455239 | biostudies-literature
Unknown Anti-Inflammatory and Antimicrobial Activities of Compounds Isolated from <i>Distichochlamys benenica</i>.
| S-EPMC8046538 | biostudies-literature
Unknown Nigrosphaerin A a new isochromene derivative from the endophytic fungus Nigrospora sphaerica.
| S-EPMC5047436 | biostudies-literature
Unknown Epigenetic Modifiers Revamp Secondary Metabolite Production in Endophytic <i>Nigrospora sphaerica</i>.
| S-EPMC8678036 | biostudies-literature
Unknown Antioxidant and α-glucosidase inhibitory activities of compound isolated from Stachytarpheta jamaicensis (L) Vahl. leaves.
| S-EPMC10616201 | biostudies-literature
Genomics Nigrospora sphaerica strain:ZJJ_C1
| PRJNA726343 | ENA
Unknown Cornus officinalis Ethanolic Extract with Potential Anti-Allergic, Anti-Inflammatory, and Antioxidant Activities.
| S-EPMC7692184 | biostudies-literature