Nigrosphaerin A a new isochromene derivative from the endophytic fungus Nigrospora sphaerica.

ABSTRACT: Nigrosphaerin A, a new isochromene derivative (1), was isolated from the endophytic fungus Nigrospora sphaerica and chemically identified as 3-(3,4-dihydroxyphenyl)-4,6,8-trihydroxy-1H-isochromen-1-one-6-O-?-d-glucopyranoside. In addition nineteen known compounds (2-20) were isolated from the same fungus and chemically identified. Compounds (1-3, 5, and 7-16) were isolated for the first time from this fungus. In vitro antileukemic, antileishmanial, antifungal, antibacterial and antimalarial activities of (1-20) were examined. Compounds 5, 7, 9 and 10 showed good antileukemic activity against HL60 cells with IC50 values of 0.03, 0.39, 0.2 and 0.4 ?g/mL, respectively and against K562 cells with IC50 values of 0.35, 0.35, 0.49 and 0.01 ?g/mL, respectively. Compounds 3, 4 and 6 showed moderate antileishmanial activity with IC50 values of 30.2, 26.4 and 36.4 ?g/ml, respectively. Compound 7 showed moderate antifungal activity against Cryptococcus neoformans with IC50 value of 14.8 ?g/mL.

SUBMITTER: Metwaly AM 

PROVIDER: S-EPMC5047436 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature