Ontology highlight
ABSTRACT:
SUBMITTER: Ouadah Y
PROVIDER: S-EPMC6782070 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Cell 20191001 2
Pulmonary neuroendocrine (NE) cells are neurosensory cells sparsely distributed throughout the bronchial epithelium, many in innervated clusters of 20-30 cells. Following lung injury, NE cells proliferate and generate other cell types to promote epithelial repair. Here, we show that only rare NE cells, typically 2-4 per cluster, function as stem cells. These fully differentiated cells display features of classical stem cells. Most proliferate (self-renew) following injury, and some migrate into ...[more]