Ontology highlight
ABSTRACT:
SUBMITTER: Chen HJ
PROVIDER: S-EPMC6400536 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Chen Huanhuan Joyce HJ Poran Asaf A Unni Arun M AM Huang Sarah Xuelian SX Elemento Olivier O Snoeck Hans-Willem HW Varmus Harold H
The Journal of experimental medicine 20190208 3
Cancer models based on cells derived from human embryonic stem cells (hESCs) may reveal why certain constellations of genetic changes drive carcinogenesis in specialized lineages. Here we demonstrate that inhibition of NOTCH signaling induces up to 10% of lung progenitor cells to form pulmonary neuroendocrine cells (PNECs), putative precursors to small cell lung cancers (SCLCs), and we can increase PNECs by reducing levels of retinoblastoma (RB) proteins with inhibitory RNA. Reducing levels of T ...[more]