Ontology highlight
ABSTRACT:
SUBMITTER: Gatsogiannis C
PROVIDER: S-EPMC6783313 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20191003 10
The ClpXP machinery is a two-component protease complex that performs targeted protein degradation in bacteria and mitochondria. The complex consists of the AAA+ chaperone ClpX and the peptidase ClpP. The hexameric ClpX utilizes the energy of ATP binding and hydrolysis to engage, unfold and translocate substrates into the catalytic chamber of tetradecameric ClpP, where they are degraded. Formation of the complex involves a symmetry mismatch, because hexameric AAA+ rings bind axially to the oppos ...[more]