Ontology highlight
ABSTRACT:
SUBMITTER: Deng Q
PROVIDER: S-EPMC6783334 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Statistical methods in medical research 20190408 2
Traditionally, statistical methods for futility analysis are developed based on a single study. To establish a drug's effectiveness, usually at least two adequate and well-controlled studies need to demonstrate convincing evidence on its own. Therefore, in a standard clinical development program in chronic diseases, two independent studies are generally conducted for drug registration. This paper proposes a statistical method to combine interim data from two independent and similar studies for i ...[more]