Dataset Information

Dissemination of carbapenemase-producing Enterobacteriaceae harbouring bla_NDM or bla_IMI in local market foods of Yangon, Myanmar.

ABSTRACT: The spread of carbapenemase-producing Enterobacteriaceae (CPE) poses a serious threat to clinical practice and public health. These bacteria are present both in clinical settings and non-clinical environments. The presence of CPE in food stuffs has been reported, but sporadically so. Here, we screened for CPE in meat, seafood, and vegetable samples from local markets of Yangon, Myanmar. We obtained 27 CPE isolates from 93 food samples and identified 13 as Escherichia coli, six as Klebsiella pneumoniae, seven as Enterobacter cloacae complex, and one as Serratia marcescens. All except the E. cloacae complex harboured the carbapenemase genes bla_NDM-1 or bla_NDM-5, while all Enterobacter isolates carried the carbapenemase gene bla_IMI-1. The bla_IMI-1 gene was located in putative mobile elements EcloIMEX-2, -3, or -8. Using multi-locus sequence typing, E. coli, K. pneumoniae, and E. cloacae complex isolates were classified into 10, six, and five different sequence types, respectively. Our results demonstrate that diverse organisms with various carbapenemase genes are widespread in the market foods in Yangon, highlighting the need for promoting proper food hygiene and effective measures to prevent further dissemination.

SUBMITTER: Sugawara Y

PROVIDER: S-EPMC6783431 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Dissemination of carbapenemase-producing Enterobacteriaceae harbouring bla<sub>NDM</sub> or bla<sub>IMI</sub> in local market foods of Yangon, Myanmar.

Sugawara Yo Y Hagiya Hideharu H Akeda Yukihiro Y Aye Mya Mya MM Myo Win Hpoo Pwint HP Sakamoto Noriko N Shanmugakani Rathina Kumar RK Takeuchi Dan D Nishi Isao I Ueda Akiko A Htun Moh Moh MM Tomono Kazunori K Hamada Shigeyuki S

Scientific reports 20191008 1

The spread of carbapenemase-producing Enterobacteriaceae (CPE) poses a serious threat to clinical practice and public health. These bacteria are present both in clinical settings and non-clinical environments. The presence of CPE in food stuffs has been reported, but sporadically so. Here, we screened for CPE in meat, seafood, and vegetable samples from local markets of Yangon, Myanmar. We obtained 27 CPE isolates from 93 food samples and identified 13 as Escherichia coli, six as Klebsiella pneu ...[more]

PMID: 31595007

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Project description:Carbapenem-resistant Enterobacteriaceae strains have emerged as a serious threat to global public health. In recent years, blaIMI, a carbapenemase gene that drew less attention before, has been increasingly detected in both clinical and environmental settings. However, the environmental distribution and transmission of blaIMI, especially in aquaculture, require systematic investigation. In this study, the blaIMI gene was detected in fish (n = 1), sewage (n = 1), river water (n = 1), and aquaculture pond water samples (n = 17) collected from Jiangsu, China, demonstrating a relatively high sample-positive ratio of 12.4% (20/161). Thirteen blaIMI-2- or blaIMI-16-carrying Enterobacter asburiae strains were isolated from blaIMI-positive samples of aquatic products and aquaculture ponds. We also identified a novel transposon (Tn7441) carrying blaIMI-16 and a conserved region containing several truncated insertion sequence (IS) elements harboring blaIMI-2, all of which may play important roles in blaIMI mobilization. The occurrence of blaIMI-carrying Enterobacter asburiae in aquaculture-related water samples and fish samples highlights the risk of transmission of blaIMI-carrying strains through the food chain and the need for effective measures to prevent further dissemination. IMPORTANCE IMI carbapenemases have been detected in clinical isolates of many bacterial species with systemic infection and cause a further burden on clinical treatment in China, but their source and distribution are still unclear. The study systematically investigated the distribution and transmission of the blaIMI gene in aquaculture-related water bodies and aquatic products in Jiangsu Province, China, which is famous for its rich water resources and developed aquaculture industry. The relatively high prevalence of blaIMI in aquaculture samples and the identification of novel mobile elements harboring blaIMI enhance our knowledge of blaIMI gene distribution and highlight the public health risk and urgency of surveillance of aquaculture water systems in China.

Dataset Information

Dissemination of carbapenemase-producing Enterobacteriaceae harbouring bla_NDM or bla_IMI in local market foods of Yangon, Myanmar.

Publications

Dissemination of carbapenemase-producing Enterobacteriaceae harbouring bla<sub>NDM</sub> or bla<sub>IMI</sub> in local market foods of Yangon, Myanmar.

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Dataset Information

Dissemination of carbapenemase-producing Enterobacteriaceae harbouring blaNDM or blaIMI in local market foods of Yangon, Myanmar.

Publications

Dissemination of carbapenemase-producing Enterobacteriaceae harbouring bla<sub>NDM</sub> or bla<sub>IMI</sub> in local market foods of Yangon, Myanmar.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dissemination of carbapenemase-producing Enterobacteriaceae harbouring bla_NDM or bla_IMI in local market foods of Yangon, Myanmar.