A Metabolomics Approach to Unravel Cricket Paralysis Virus Infection in Silkworm Bm5 Cells.

ABSTRACT: How a host metabolism responds to infection with insect viruses and how it relates to pathogenesis, is little investigated. Our previous study observed that Cricket paralysis virus (CrPV, Dicistroviridae) causes short term persistence in silkworm Bm5 cells before proceeding to acute infection. In this study, a metabolomics approach based on high resolution mass spectrometry was applied to investigate how a host metabolism is altered during the course of CrPV infection in Bm5 cells and which changes are characteristic for the transition from persistence to pathogenicity. We observed that CrPV infection led to significant and stage-specific metabolic changes in Bm5 cells. Differential metabolites abundance and pathway analysis further identified specific metabolic features at d

SUBMITTER: Wang LL 

PROVIDER: S-EPMC6784103 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature