Dataset Information

The Influence of Body Mass Index at Diagnosis on Cognitive Decline in Parkinson's Disease.

ABSTRACT:

Background and purpose

Associations between alterations in body mass index (BMI) and cognitive function have been reported in Parkinson's disease (PD). We investigated whether the BMI at a PD diagnosis is associated with cognitive decline and the future development of dementia.

Methods

We recruited 70 patients with de novo PD who underwent neuropsychological testing every 3 years and were followed up for more than 6 years. We classified patients into the following three groups based on their BMI at the diagnosis: under-/normal weight (n=21), overweight (n=22), and obese (n=27). We evaluated differences in the rate of cognitive decline over time among the groups using linear mixed models and the conversion rate to dementia using survival analysis.

Results

The obese patients with PD showed a slower deterioration of global cognitive function as well as language and memory functions than did the under-/normal-weight group during the 6-year follow-up. The three BMI groups showed different rates of conversion to dementia (log-rank test: p=0.026). The combined overweight and obese group showed a lower risk of developing dementia compared with the under-/normal-weight group (hazard ratio= 0.36, 95% CI=0.12-0.82, p=0.046).

Conclusions

We have demonstrated that a higher-than-normal BMI at the time of a PD diagnosis has a protective effect against the deterioration of cognitive function and the conversion to dementia.

SUBMITTER: Yoo HS

PROVIDER: S-EPMC6785479 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Publications

The Influence of Body Mass Index at Diagnosis on Cognitive Decline in Parkinson's Disease.

Yoo Han Soo HS Chung Seok Jong SJ Lee Phil Hyu PH Sohn Young H YH Kang Suk Yun SY

Journal of clinical neurology (Seoul, Korea) 20191001 4

<h4>Background and purpose</h4>Associations between alterations in body mass index (BMI) and cognitive function have been reported in Parkinson's disease (PD). We investigated whether the BMI at a PD diagnosis is associated with cognitive decline and the future development of dementia.<h4>Methods</h4>We recruited 70 patients with <i>de novo</i> PD who underwent neuropsychological testing every 3 years and were followed up for more than 6 years. We classified patients into the following three gro ...[more]

PMID: 31591841

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Project description:ObjectiveTo examine the associations between BMI categories and subsequent 3-year cognitive decline among older adults, and to test whether physical activity modifies the associations.MethodsStudy sample included n = 1028 cognitively unimpaired older adults participating in the Étude sur la Santé des Aînés (ESA)-Services longitudinal study and followed 3 years later. Cognitive decline was defined as a decrease of > 3 points in MMSE scores between baseline and follow-up. BMI categories (normal weight (reference), underweight, overweight, obese) were derived from self-reported weight and height. Moderate to vigorous physical activity of ≥20 min (# of times per week) was self-reported. The presence of chronic disorders was ascertained from administrative and self-reported data. Logistic regression analyses were used to study the risk of cognitive decline associated with BMI categories stratified by weekly physical activity (≥140 min), the presence of metabolic, cardiovascular and anxio-depressive disorders.ResultsIn the overall sample, there was no evidence that underweight, overweight, or obesity, as compared to normal weight, was associated with cognitive decline, after adjusting for sociodemographic, lifestyle factors, and comorbidities. Individuals with overweight reporting high physical activity had lower odds of cognitive decline (OR = 0.25, 95% CI = 0.07-0.89), whereas no association was observed in individuals with overweight reporting low physical activity (OR = 0.85, 95% CI = 0.41-1.75). Among participants with metabolic and cardiovascular disorders, individuals with overweight reporting high physical activity had lower odds of cognitive decline (OR = 0.09, 95% CI = 0.01-0.59 and OR = 0.03, 95% CI = 0.01-0.92 respectively), whereas no association was observed in those with low physical activity.ConclusionPhysical activity modifies the association between overweight and cognitive decline in older adults overall, as in those with metabolic and cardiovascular disorders. Results highlight the importance of promoting and encouraging regular physical activity in older adults with overweight as prevention against cognitive decline.

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Dataset Information

The Influence of Body Mass Index at Diagnosis on Cognitive Decline in Parkinson's Disease.

Background and purpose

Methods

Results

Conclusions

Publications

The Influence of Body Mass Index at Diagnosis on Cognitive Decline in Parkinson's Disease.

Similar Datasets

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