Ontology highlight
ABSTRACT:
SUBMITTER: Zhou FL
PROVIDER: S-EPMC6786357 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Acta pharmacologica Sinica 20190528 9
Chemical genomics has been applied extensively to evaluate small molecules that modulate biological processes in Saccharomyces cerevisiae. Here, we use yeast as a surrogate system for studying compounds that are active against metazoan targets. Large-scale chemical-genetic profiling of thousands of synthetic and natural compounds from the Chinese National Compound Library identified those with high-confidence bioprocess target predictions. To discover compounds that have the potential to functio ...[more]