Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC6786402 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Chen Zhuo Z Tong Lin-Jiang LJ Tang Bai-You BY Liu Hong-Yan HY Wang Xin X Zhang Tao T Cao Xian-Wen XW Chen Yi Y Li Hong-Lin HL Qian Xu-Hong XH Xu Yu-Fang YF Xie Hua H Ding Jian J
Acta pharmacologica Sinica 20181128 6
The fibroblast growth factor receptors (FGFRs) are increasingly considered attractive targets for therapeutic cancer intervention due to their roles in tumor metastasis and angiogenesis. Here, we identified a new selective FGFR inhibitor, C11, and assessed its antitumor activities. C11 was a selective FGFR1 inhibitor with an IC<sub>50</sub> of 19 nM among a panel of 20 tyrosine kinases. C11 inhibited cell proliferation in various tumors, particularly bladder cancer and breast cancer. C11 also in ...[more]