Ontology highlight
ABSTRACT:
SUBMITTER: Liu P
PROVIDER: S-EPMC6786432 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Liu Ping P Yin Yu-Ling YL Wang Ting T Hou Li L Wang Xiao-Xi XX Wang Man M Zhao Guan-Guan GG Shi Yi Y Xu H Eric HE Jiang Yi Y
Acta pharmacologica Sinica 20190304 9
5-HT<sub>4</sub>R, 5-HT<sub>6</sub>R, and 5-HT<sub>7A</sub>R are three constitutively active G<sub>s</sub>-coupled 5-HT receptors that have key roles in brain development, learning, memory, cognition, and other physiological processes in the central nervous system. In addition to G<sub>s</sub> signaling cascade mediated by these three 5-HT receptors, the ERK1/2 signaling which is dependent on cyclic adenosine monophosphate (cAMP) production and protein kinase A (PKA) activation downstream of G<s ...[more]