Ontology highlight
ABSTRACT:
SUBMITTER: Sachdeva R
PROVIDER: S-EPMC6787003 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Scientific reports 20191010 1
Despite advances in therapy, glioblastoma remains an incurable disease with a dismal prognosis. Recent studies have implicated cancer stem cells within glioblastoma (glioma stem cells, GSCs) as mediators of therapeutic resistance and tumor progression. In this study, we investigated the role of the transforming growth factor-β (TGF-β) superfamily, which has been found to play an integral role in the maintenance of stem cell homeostasis within multiple stem cell systems, as a mediator of stem-lik ...[more]