Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.
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ABSTRACT:
SUBMITTER: Horgusluoglu-Moloch E
PROVIDER: S-EPMC6787090 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.
Horgusluoglu-Moloch Emrin E Risacher Shannon L SL Crane Paul K PK Hibar Derrek D Thompson Paul M PM Saykin Andrew J AJ Nho Kwangsik K
Scientific reports 20191010 1
Adult neurogenesis occurs in the dentate gyrus of the hippocampus during adulthood and contributes to sustaining the hippocampal formation. To investigate whether neurogenesis-related pathways are associated with hippocampal volume, we performed gene-set enrichment analysis using summary statistics from a large-scale genome-wide association study (N = 13,163) of hippocampal volume from the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium and two year hippocampal volume ...[more]
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