Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.
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ABSTRACT:
SUBMITTER: Vojinovic D
PROVIDER: S-EPMC6158214 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.
Vojinovic Dina D Adams Hieab H HH Jian Xueqiu X Yang Qiong Q Smith Albert Vernon AV Bis Joshua C JC Teumer Alexander A Scholz Markus M Armstrong Nicola J NJ Hofer Edith E Saba Yasaman Y Luciano Michelle M Bernard Manon M Trompet Stella S Yang Jingyun J Gillespie Nathan A NA van der Lee Sven J SJ Neumann Alexander A Ahmad Shahzad S Andreassen Ole A OA Ames David D Amin Najaf N Arfanakis Konstantinos K Bastin Mark E ME Becker Diane M DM Beiser Alexa S AS Beyer Frauke F Brodaty Henry H Bryan R Nick RN Bülow Robin R Dale Anders M AM De Jager Philip L PL Deary Ian J IJ DeCarli Charles C Fleischman Debra A DA Gottesman Rebecca F RF van der Grond Jeroen J Gudnason Vilmundur V Harris Tamara B TB Homuth Georg G Knopman David S DS Kwok John B JB Lewis Cora E CE Li Shuo S Loeffler Markus M Lopez Oscar L OL Maillard Pauline P El Marroun Hanan H Mather Karen A KA Mosley Thomas H TH Muetzel Ryan L RL Nauck Matthias M Nyquist Paul A PA Panizzon Matthew S MS Pausova Zdenka Z Psaty Bruce M BM Rice Ken K Rotter Jerome I JI Royle Natalie N Satizabal Claudia L CL Schmidt Reinhold R Schofield Peter R PR Schreiner Pamela J PJ Sidney Stephen S Stott David J DJ Thalamuthu Anbupalam A Uitterlinden Andre G AG Valdés Hernández Maria C MC Vernooij Meike W MW Wen Wei W White Tonya T Witte A Veronica AV Wittfeld Katharina K Wright Margaret J MJ Yanek Lisa R LR Tiemeier Henning H Kremen William S WS Bennett David A DA Jukema J Wouter JW Paus Tomas T Wardlaw Joanna M JM Schmidt Helena H Sachdev Perminder S PS Villringer Arno A Grabe Hans Jörgen HJ Longstreth W T WT van Duijn Cornelia M CM Launer Lenore J LJ Seshadri Sudha S Ikram M Arfan MA Fornage Myriam M
Nature communications 20180926 1
The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chrom ...[more]
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