Ontology highlight
ABSTRACT:
SUBMITTER: Pepineli AC
PROVIDER: S-EPMC6787522 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Pepineli Afonso Carrasco AC Alves Hugo Vicentin HV Tiyo Bruna Tiaki BT Macedo Luciana Conci LC Visentainer Lorena L de Lima Neto Quirino Alves QA Zacarias Joana Maira Valentini JMV Sell Ana Maria AM Visentainer Jeane Eliete Laguila JEL
Frontiers in immunology 20191004
Vitamin D, together with its nuclear receptor (VDR), plays an important role in modulating the immune response, decreasing the inflammatory process. Some polymorphisms of the <i>VDR</i> gene, such as <i>Bsm</i>I (G>A rs1544410)<i>, Apa</i>I (G>T rs7975232), and <i>Taq</i>I (T>C rs731236) could affect its stability and mRNA transcription activity, while <i>Fok</i>I T>C (rs2228570) gives a truncated protein with three fewer amino acids and more efficiency in binding vitamin D. This study evaluated ...[more]