Phenotyping diabetic cardiomyopathy in Europeans and South Asians.

ABSTRACT: BACKGROUND:The pathogenesis and cardiovascular impact of type 2 diabetes (T2D) may be different in South Asians compared with other ethnic groups. The phenotypic characterization of diabetic cardiomyopathy remains debated and little is known regarding differences in T2D-related cardiovascular remodeling across ethnicities. We aimed to characterize the differences in left ventricular (LV) diastolic and systolic function, LV structure, myocardial tissue characteristics and aortic stiffness between T2D patients and controls and to assess the differences in T2D-related cardiovascular remodeling between South Asians and Europeans. METHODS:T2D patients and controls of South Asian and European descent underwent 3 Tesla cardiovascular magnetic resonance imaging (CMR) and cardiac proton-magnetic resonance spectroscopy (1H-MRS). Differences in cardiovascular parameters between T2D patients and controls were examined using ANCOVA and were reported as mean (95% CI). Ethnic group comparisons in the association of T2D with cardiovascular remodeling were made by adding the interaction term between ethnicity and diabetes status to the model. RESULTS:A total of 131 individuals were included (54 South Asians [50.1?±?8.7 years, 33% men, 33 patients vs. 21 controls) and 77 Europeans (58.8?±?7.0 years, 56% men, 48 patients vs. 29 controls)]. The ratio of the transmitral early and late peak filling rate (E/A) was lower in T2D patients compared with controls, in South Asians [-?0.20 (-?0.36; -?0.03), P?=?0.021] and Europeans [-?0.20 (-?0.36; -?0.04), P?=?0.017], whereas global longitudinal strain and aortic pulse wave velocity were similar. South Asian T2D patients had a higher LV mass [+?22 g (15; 30), P?

SUBMITTER: Paiman EHM 

PROVIDER: S-EPMC6788052 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature