Ontology highlight
ABSTRACT:
SUBMITTER: Parker JL
PROVIDER: S-EPMC6789118 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Parker Joanne L JL Corey Robin A RA Stansfeld Phillip J PJ Newstead Simon S
Nature communications 20191011 1
Nucleotide sugars are the activated form of monosaccharides used by glycosyltransferases during glycosylation. In eukaryotes the SLC35 family of solute carriers are responsible for their selective uptake into the Endoplasmic Reticulum or Golgi apparatus. The structure of the yeast GDP-mannose transporter, Vrg4, revealed a requirement for short chain lipids and a marked difference in transport rate between the nucleotide sugar and nucleoside monophosphate, suggesting a complex network of regulato ...[more]