Ontology highlight
ABSTRACT:
SUBMITTER: Ahuja S
PROVIDER: S-EPMC6508934 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Ahuja Shivani S Whorton Matthew R MR
eLife 20190415
Nucleotide-sugar transporters (NSTs) are critical components of the cellular glycosylation machinery. They transport nucleotide-sugar conjugates into the Golgi lumen, where they are used for the glycosylation of proteins and lipids, and they then subsequently transport the nucleotide monophosphate byproduct back to the cytoplasm. Dysregulation of human NSTs causes several debilitating diseases, and NSTs are virulence factors for many pathogens. Here we present the first crystal structures of a m ...[more]