Ontology highlight
ABSTRACT:
SUBMITTER: Kanakkanthara A
PROVIDER: S-EPMC6789141 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Kanakkanthara Arun A Huntoon Catherine J CJ Hou Xiaonan X Zhang Minzhi M Heinzen Ethan P EP O'Brien Daniel R DR Oberg Ann L AL John Weroha S S Kaufmann Scott H SH Karnitz Larry M LM
Nature communications 20191011 1
Reduced BRCA1 expression causes homologous recombination (HR) repair defects in high-grade serous ovarian cancers (HGSOCs). Here, we demonstrate that BRCA1 is transcriptionally activated by a previously unknown function of ZC3H18. We show that ZC3H18 is a DNA-binding protein that interacts with an E2F site in the BRCA1 promoter where it facilitates recruitment of E2F4 to an adjacent E2F site to promote BRCA1 transcription. Consistent with ZC3H18 role in activating BRCA1 expression, ZC3H18 deplet ...[more]