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Early detection and monitoring of cerebral ischemia using calcium-responsive MRI probes.

ABSTRACT: Cerebral ischemia is one of the leading causes of mortality and disability in infants and adults and its timely diagnosis is essential for an efficient treatment. We present a methodology for fast detection and real-time monitoring of fluctuations of calcium ions associated with focal ischemia using a molecular functional MRI approach. We used a dinuclear paramagnetic gadolinium(III) complex chelate that changes MR image contrast through its reversible interaction with extracellular calcium ions, while applying a remote transient middle cerebral artery occlusion as a model for ischemic stroke. Our method sensitively recognizes the onset and follows the dynamics of the ischemic core and penumbra with submillimeter spatial and second-scale temporal resolution, thus paving the way for noninvasive monitoring and development of targeted treatment strategies for cerebral ischemia.

SUBMITTER: Savic T 

PROVIDER: S-EPMC6789561 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Early detection and monitoring of cerebral ischemia using calcium-responsive MRI probes.

Savić Tanja T   Gambino Giuseppe G   Gambino Giuseppe G   Bokharaie Vahid S VS   Noori Hamid R HR   Logothetis Nikos K NK   Angelovski Goran G  

Proceedings of the National Academy of Sciences of the United States of America 20190923 41

Cerebral ischemia is one of the leading causes of mortality and disability in infants and adults and its timely diagnosis is essential for an efficient treatment. We present a methodology for fast detection and real-time monitoring of fluctuations of calcium ions associated with focal ischemia using a molecular functional MRI approach. We used a dinuclear paramagnetic gadolinium(III) complex chelate that changes MR image contrast through its reversible interaction with extracellular calcium ions  ...[more]

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