Ontology highlight
ABSTRACT:
SUBMITTER: Yu J
PROVIDER: S-EPMC6789733 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20190923 41
We present a statistical framework to model the spatial distribution of molecules based on a single-molecule localization microscopy (SMLM) dataset. The latter consists of a collection of spatial coordinates and their associated uncertainties. We describe iterative parameter-estimation algorithms based on this framework, as well as a sampling algorithm to numerically evaluate the complete posterior distribution. We demonstrate that the inverse computation can be viewed as a type of image restora ...[more]