Unknown

Dataset Information

0

High-level expression of protein tyrosine phosphatase non-receptor 12 is a strong and independent predictor of poor prognosis in prostate cancer.


ABSTRACT: BACKGROUND:Protein tyrosine phosphatase non-receptor 12 (PTPN12) is ubiquitously tyrosine phosphatase with tumor suppressive properties. METHODS:PTPN12 expression was analyzed by immunohistochemistry on a tissue microarray with 13,660 clinical prostate cancer specimens. RESULTS:PTPN12 staining was typically absent or weak in normal prostatic epithelium but seen in the majority of cancers, where staining was considered weak in 26.5%, moderate in 39.9%, and strong in 4.7%. High PTPN12 staining was associated with high pT category, high classical and quantitative Gleason grade, lymph node metastasis, positive surgical margin, high Ki67 labeling index and early prostate specific antigen recurrence (p?

SUBMITTER: Weidemann SA 

PROVIDER: S-EPMC6790047 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications


<h4>Background</h4>Protein tyrosine phosphatase non-receptor 12 (PTPN12) is ubiquitously tyrosine phosphatase with tumor suppressive properties.<h4>Methods</h4>PTPN12 expression was analyzed by immunohistochemistry on a tissue microarray with 13,660 clinical prostate cancer specimens.<h4>Results</h4>PTPN12 staining was typically absent or weak in normal prostatic epithelium but seen in the majority of cancers, where staining was considered weak in 26.5%, moderate in 39.9%, and strong in 4.7%. Hi  ...[more]

Similar Datasets

| S-EPMC7877177 | biostudies-literature
| S-EPMC7196962 | biostudies-literature
| S-EPMC4521853 | biostudies-literature
| S-EPMC7013067 | biostudies-literature
| S-EPMC9033838 | biostudies-literature
| S-EPMC10006782 | biostudies-literature
| S-EPMC7938604 | biostudies-literature
| S-EPMC5567055 | biostudies-literature
| S-EPMC8129400 | biostudies-literature
| S-EPMC10022215 | biostudies-literature