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15 N Hyperpolarization of Dalfampridine at Natural Abundance for Magnetic Resonance Imaging.

ABSTRACT: Signal Amplification by Reversible Exchange (SABRE) is a promising method for NMR signal enhancement and production of hyperpolarized molecules. As nuclear spin relaxation times of heteronuclei are usually much longer than those of protons, SABRE-based hyperpolarization of heteronuclei in molecules is highly important in the context of biomedical applications. In this work, we demonstrate that the SLIC-SABRE technique can be successfully used to hyperpolarize 15 N nuclei in dalfampridine. The high polarization level of ca. 8?% achieved in this work made it possible to acquire 15 N MR images at natural abundance of the 15 N nuclei for the first time.

SUBMITTER: Skovpin IV

PROVIDER: S-EPMC6790219 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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15 N Hyperpolarization of Dalfampridine at Natural Abundance for Magnetic Resonance Imaging.

Skovpin Ivan V IV Svyatova Alexandra A Chukanov Nikita N Chekmenev Eduard Y EY Kovtunov Kirill V KV Koptyug Igor V IV

Chemistry (Weinheim an der Bergstrasse, Germany) 20190909 55

Signal Amplification by Reversible Exchange (SABRE) is a promising method for NMR signal enhancement and production of hyperpolarized molecules. As nuclear spin relaxation times of heteronuclei are usually much longer than those of protons, SABRE-based hyperpolarization of heteronuclei in molecules is highly important in the context of biomedical applications. In this work, we demonstrate that the SLIC-SABRE technique can be successfully used to hyperpolarize 15 N nuclei in dalfamprid ...[more]

PMID: 31338889

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