Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases.

ABSTRACT:

Background

Retinal optical coherence tomography findings in Lewy body diseases and their implications for visual outcomes remain controversial. We investigated whether region-specific thickness analysis of retinal layers could improve the detection of macular atrophy and unravel its association with visual disability in Parkinson's disease.

Methods

Patients with idiopathic Parkinson's disease (n = 63), dementia with Lewy bodies (n = 8), and E46K mutation carriers in the α-synuclein gene (E46K-SNCA) (n = 4) and 34 controls underwent Spectralis optical coherence tomography macular scans and a comprehensive battery of visual function and cognition tests. We computed mean retinal layer thicknesses of both eyes within 1-, 2-, 3-, and 6-mm diameter macular discs and in concentric

SUBMITTER: Murueta-Goyena A 

PROVIDER: S-EPMC6790692 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature