The genetic and clinico-pathological profile of early-onset progressive supranuclear palsy.

ABSTRACT:

Background

Studies on early-onset presentations of progressive supranuclear palsy (PSP) have been limited to those where a rare monogenic cause has been identified. Here, we have defined early-onset PSP (EOPSP) and investigated its genetic and clinico-pathological profile in comparison with late-onset PSP (LOPSP) and Parkinson's disease (PD).

Methods

We included subjects from the Queen Square Brain Bank, PROSPECT-UK study, and Tracking Parkinson's study. Group comparisons of data were made using Welch's t-test and Kruskal-Wallis analysis of variance. EOPSP was defined as the youngest decile of motor age at onset (≤55 years) in the Queen Square Brain Bank PSP case series.

Results

We identified 33 EOPSP, 328 LOPSP, and 2000 PD subjects. The early clinical features of EO

SUBMITTER: Jabbari E 

PROVIDER: S-EPMC6790973 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature